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. 2022 Jun 6;13:823121. doi: 10.3389/fimmu.2022.823121

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Copyright © 2022 Haist, Ries, Gunzer, Bednarczyk, Siegel, Kuske, Grabbe, Radsak, Bros and Teschner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PMN derived from CD18^Ly6G cKO mice generate lower amounts of TNF-α after previous stimulation with LPS, CpG or R848. We have purified PMN from CD18^fl/fl (n=3) mice and CD18^Ly6G cKO (n=3) mice and incubated them for 24h at the indicated conditions. After 3h and 24h supernatants have been taken and were analyzed using a CBA. Results show significantly lower levels of TNF-α in supernatants derived from CD18^Ly6G cKO mice. *p<0.05, ^#p<0.05 when comparing cytokine concentrations from supernatants at 3 vs 24h.