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. 2022 Jun 6;10:906713. doi: 10.3389/fcell.2022.906713

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Copyright © 2022 Wille and Sridharan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DOT1L lineage-specific knock-out (KO) mouse models. Numerous lineage DOT1L-KO mouse models using tissue-specific CRE drivers have recently been reported (Table 2). Total DOT1L-KO is embryonic lethal around E11.5 (Table 1). Tissue-specific KOs have various phenotypes, but the overwhelming majority have decreased or impaired differentiation. Perinatal lethality is indicated in red bold, disrupted differentiation in black bold, and no phenotype in black italics. Created with BioRender.com.