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. 2022 May 31;29:16–35. doi: 10.1016/j.omtn.2022.05.034

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© 2022 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Exosomal non-coding RNAs have an effect on EMT

Tumor-cell-derived exosomal non-coding RNAs regulate target molecules and signaling pathways to promote tumor cell EMT. In renal clear cell carcinoma, CSCs-derived exosomal miR-19b-3p suppresses PTEN expression in cancer cells, promoting EMT. Exosomes from highly metastatic CRC cells transfer miR-106b-3p to low-metastatic CRC cells and inhibit DLC-1, thereby promoting EMT. Exosomal lnc-sox2ot secreted by highly invasive PDAC cells promotes low-invasive PDAC cell EMT via miR-200s/Sox2/snail. In bladder urothelial carcinoma, cancer cells secrete exosomal circ-PRMT5 and promote EMT in recipient cancer cells via miR-30c/snail1/E-cadherin. Exosomal circ-NRIP1 from gastric cancer cells promotes EMT via miR-149-5p/AKT1/mTOR.