Table 1.
The role of exosomal non-coding RNA in tumor metastasis
| Exosomal non-coding RNA | Donor cell | Recipient cell | Role in tumor metastasis |
|---|---|---|---|
| miR-21, miR-10b23 | HCC cell | HCC cell | promoting HCC cells migration, invasion, and EMT |
| miR-15524 | gastric cancer cell | human umbilical vein endothelial cell (HUVEC) | promoting angiogenesis of HUVECs |
| miR-196a-125 | gastric cancer cell | gastric cancer cell | enhancing invasion ability of gastric cancer cells |
| miR-499a-5p26 | lung adenocarcinoma cell | lung adenocarcinoma cell | promoting cancer cell migration and epithelial-mesenchymal transition (EMT) |
| miR-122927 | colorectal cancer (CRC) cell | HUVEC | promoting tubulogenesis of HUVECs |
| miR-25-3p28 | CRC cell | HUVEC | promoting vascular permeability and angiogenesis to induce vascular leakiness |
| miR-25-3p, miR-92a-3p29 | liposarcoma cell | macrophage | inducing IL-6 release from macrophages |
| miR-106a30 | gastric cancer cell | peritoneal mesothelial cell | inducing peritoneal mesothelial cell damage, apoptosis, migration, and mesothelial-to-mesenchymal transition |
| miR-125b-5p31 | melanoma cell | macrophage | inducing the tumor-promoting phenotype of tumor-associated macrophages |
| miR-1910-3p32 | breast cancer cell | breast cancer cell | promoting migration of breast cancer cells |
| miR-933 | nasopharyngeal carcinoma cell | HUVEC | inhibiting HUVECs tube formation and migration |
| lnc-FMR1-AS134 | esophageal CSC | non-CSC | promoting stemness phenotypes of non-CSCs |
| lnc-UCA135 | CRC cell | CRC cell | promoting proliferation and migration of CRC cells |
| lnc-MALAT136 | CRC cell | CRC cell | promoting invasion and migration |
| lnc-RUNX2-AS137 | myeloma cell | mesenchymal stem cell | inhibiting the osteogenesis of mesenchymal stem cells |
| lnc-PTENP138 | normal cell | bladder cancer cell | suppressing bladder cancer cell invasion and migration |
| circ-MMP239 | HCC cell | normal liver cell | promoting the malignant phenotype formation of normal liver cells |
| circ-000028440 | cholangiocarcinoma cell | surrounding normal cell | promoting the migration and proliferation of surrounding normal cells and suppressing their apoptosis |
| circ-SATB241 | non-small cell lung cancer cell | lung cancer cell and bronchial epithelial cell | promoting the migration and invasion of lung cancer cells and inducing abnormal proliferation of bronchial epithelial cell |