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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Mol Pharm. 2022 Jan 3;19(2):592–601. doi: 10.1021/acs.molpharmaceut.1c00681

Figure 3.

Figure 3.

InCPMV is a poor TLR7 stimulant, leading to low cytokine induction compared to CPMV. Splenocyte assays established previously19 were set up from C57BL6, MyD88−/−, TLR7−/−, TLR2−/−, TLR4−/−, TLR5−/−, and TLR9−/− mice (n = 3/strain). Supernatant was analyzed by (A,B) IL-6 ELISA and (C,D) IFN-β ELISA. Data for bar graphs were calculated using unpaired Student’s t-test with p < 0.05 as *, p < 0.01 as **, and p < 0.001 as ***.