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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Platelets. 2021 Feb 9;32(6):753–760. doi: 10.1080/09537104.2021.1881948

Figure 3.

Figure 3.

Mechanistic Model for TLT-1/Fibrinogen interaction. When in the extended confirmation, the extreme height of αIIbβ3 may prevent TLT-1 interaction with fibrin(ogen). Transmigration, however, may induce the bent confirmation of αIIbβ3, allowing fibrin(ogen) to interact with TLT-1 more readily. TLT-1 - fibrinogen interaction may induce intercellular signaling that does not happen under conditions of classic hemostasis. TLT-1-fibrinogen interactions would induce TLT-1 clustering (left side), a tighter binding of fibrinogen to the platelet surface, and intercellular signaling. Without the fibrinogen interaction TLT-1 may be cleaved off of the surface more readily (right side). Figure was generated with the Swiss-PdbViewer 4.1.0, using data published in DOI: 10.2210/pdb2FRG/pdb, DOI: 10.2210/pdb3FCS/pdb, DOI: 10.2210/pdb3GHG/pdb, and DOI: 10.2210/pdb4G1M/pdb.