REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
KLF4	Abcam	Cat#ab215036
VEGFA	Proteintech	Cat#19003-1-AP; RRID: AB_2212657
MMP-9	Abcam	Cat#ab38898; RRID: AB_776512
PCNA	Proteintech	Cat#10205-2-AP; RRID: AB_2160330
Ki67	Abcam	Cat#ab16667; RRID: AB_302459
α-SMA	Abcam	Cat#ab202509; RRID: AB_2868435
CD31	Servicebio	Cat#GB11063-2
Caspase 3	Abcam	Cat#ab32351; RRID: AB_725946
GCN5	PTM-biolab	Cat#PTM-5115
Succinyl-H3K79	PTM-biolab	Cat#PTM-412
Succinyllysine	PTM-biolab	Cat#PTM-419
IgG	Abcam	Cat#ab172730; AB_2687931
ERK	Proteintech	Cat#16443-1-AP; RRID: AB_10603369
phospho-ERK	Immunoway	Cat#YP0101
JNK	Proteintech	Cat#24164-1-AP; RRID: AB_2879443
phospho-JNK	Immunoway	Cat#YP0156; RRID: AB_2895031
P38	Proteintech	Cat#14064-1-AP; RRID: AB_2878007
phospho-P38	Immunoway	Cat#YP0338; RRID: AB_2814750
GAPDH	Proteintech	Cat#60004-1-Ig; RRID: AB_2107436
Chemicals, peptides, and recombinant proteins
ECM	Sciencell	Cat#1001
DMEM	Gibco	Cat#8121409
Fetal Bovine Serum	Sciencell	Cat#0025
Endothelial cell growth supplement	Sciencell	Cat#1052
Penicillin and streptomycin	Sciencell	Cat#0503
Recombinant Human VEGF165	Proteintech	Cat#HZ-1038
GnRHa	GL Biochem	Cat#61703
HMG	Livzon	Cat#150802
hCG	Livzon	Cat#150802
ERK inhibitor (PD98059)	MedChemExpress	Cat#HY-12028
JNK inhibitor (SP600125)	MedChemExpress	Cat#HY-12041
P38 inhibitor (SB203580)	MedChemExpress	Cat#HY-10256
Lipofectamine 2000	Invitrogen	Cat#11668
RIPA lysis buffer	Best Bio	Cat#310011
Crystal Violet Staining Solution	Beyotime	Cat#C0121
Protein A-agarose	Santa cruz	Cat#sc-2001
Critical commercial assays
ChIP assay Kit	Millipore	Cat#17-295
Human VEGFA ELISA kit	Elabscience	Cat# E-EL-H0111c
Experimental models: Cell lines
HEMEC	Sciencell	Cat#7010
HEK 293T	Procell	Cat#CL-0005
Experimental models: Organisms/strains
Mice: Kunming	Charles River Laboratories	Strain Code: 202
Oligonucleotides
Human VEGFA promoter	Sangon Biotech	5′-GCTGTTTGGGAGGTCAGAAATAGG-3′; 5′-ACGCTGCTCGCTCCATTCAC-3′
Recombinant DNA
Plasmid: VEGFA promoter	This paper	N/A
Plasmid: pEGFP-KLF4	(Yu et al., 2011b)	N/A
Plasmid: KLF4(K225R)	(Yu et al., 2011b)	N/A
Plasmid: KLF4(K229R)	(Yu et al., 2011b)	N/A
Plasmid: KLF4 (K225/229R)	(Yu et al., 2011b)	N/A
Plasmid: GCN5 control vector	This paper	N/A
Plasmid: pEGFP-GCN5	This paper	N/A
Plasmid: GCN5(Y645A)	(Tong et al., 2020)	N/A
Plasmid: sh-GCN5 control vector	This paper	N/A
Plasmid:sh-GCN5 1	This paper	N/A
Plasmid:sh-GCN52	This paper	N/A
Plasmid:sh-GCN53	This paper	N/A
Adenovirus: sh-KLF4 control vector	This paper	N/A
Adenovirus: sh-KLF4 1	This paper	N/A
Adenovirus: sh-KLF4 2	This paper	N/A
Adenovirus: sh-KLF4 3	This paper	N/A
Software and algorithms
ImageJ	(Schneider et al., 2012)	https://imagej.nih.gov/ij/
GraphPad Prism Version 8.0	GraphPad	https://www.graphpad.com