. 2022 Jun 9;65:1–7. doi: 10.1016/j.breast.2022.05.007

Table 3.

Conditional logistic regression analyses of potential risk factors associated with cardiac morbidity and cardiac mortality of 494 cases and 988 matched controls after breast cancer therapy in 1998–2008.

Variables	Crude			Adjusted†
Variables	Odds Ratio	95% CI	P	Odds Ratio	95% CI	P
Dose groups for complete heart using DMEAN [Gy]
1st quintile (<1.24 Gy)	1.00^a			1.00^a
2nd quintile (≥1.24 Gy - <1.87 Gy)	1.00	0.63–1.58	.99	0.99	0.63–1.58	.98
3rd quintile (≥1.87 Gy - <2.84 Gy)	1.02	0.66–1.56	.93	1.01	0.66–1.55	.96
4th quintile (≥2.84 Gy - <4.60 Gy)	1.02	0.62–1.68	.94	1.01	0.61–1.67	.96
5th quintile (≥4.60 Gy)	1.00	0.64–1.55	.99	0.99	0.64–1.54	.97
Complete heart using DMEAN [Gy], continuous per 1 Gy	0.99	0.94–1.05	.73	0.99	0.94–1.05	.72
Dose groups for left anterior heart wall using DMEAN [Gy]
1st quintile (<1.11 Gy)	1.00^a			1.00^a
2nd quintile (≥1.11 Gy - <2.37 Gy)	1.00	0.64–1.55	.98	0.98	0.63–1.53	.94
3rd quintile (≥2.37 Gy - <7.38 Gy)	1.06	0.68–1.66	.80	1.05	0.67–1.66	.82
4th quintile (≥7.38 Gy - <15.12)	0.94	0.61–1.43	.76	0.94	0.61–1.42	.76
5th quintile (≥15.12 Gy)	0.94	0.62–1.42	.76	0.93	0.62–1.41	.74
Left anterior heart wall using DMEAN [Gy], continuous per 1 Gy	1.00	0.98–1.01	.68	1.00	0.98–1.01	.68
Chemotherapy
No	1.00^a			1.00^a
Yes	1.18	0.93–1.50	.18	1.20	0.94–1.54	.15
Endocrine therapy
No	1.00^a			1.00^a
Yes	1.05	0.80–1.39	.72	1.09	0.82–1.45	.61
BMI^b
<25.0	1.00^a			1.00^a
≥25.0	0.99	0.78–1.24	.91	0.98	0.78–1.24	.89

† Radiation-related factors are adjusted for chemotherapy, endocrine therapy and BMI. Chemotherapy, endocrine therapy and BMI are adjusted for each other and DMEAN of the complete heart as continuous variable.

Reference category.

BMI: Body Mass Index.