Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 2;28:935–947. doi: 10.1016/j.omtn.2022.05.026

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Characterization of the in vitro function of aptamers with Mincle affinity

(A) Binding characteristics of AptMincle, and its modified counterparts, with rhMincle as determined by ELONA. (B) Graphical depiction of the modifications made to the aptamer sequences (black, original; white, modified). (C) The predicted secondary and tertiary structures and docking simulation of AptMincle^CORE (purple) with Mincle (white). Box: highlighted predicted region of interaction surrounding a calcium molecule. (D) The predicted secondary and tertiary structures and docking simulation of AptMincle^RND (purple) with Mincle (white). Box: highlighted predicted region of interaction surrounding a calcium molecule. Dissociation constants were calculated on GraphPad Prism 8 using a non-linear regression binding analysis with assumed one-site target parameters.