Table 3.

Comparison of participant neurocognitive performance to population norms by hydroxyurea treatment status at evaluation

		Current Hydroxyurea			No Current Hydroxyurea			Effect of Current Hydroxyurea Use			Adjusted Effect of Current Hydroxyurea Use
Measure	Score	Mean (SD)	Cohen’s D	pFDR	Mean (SD)	Cohen’s D	pFDR	Estimatea	SE	pFDR	Estimateb	SE	pFDR
WPPSI-IV	Full Scale IQ	90 (17)	−0.60	0.02	93 (15)	−0.45	0.05	−2.96	4.16	0.98	−0.56	4.90	0.91
WPPSI-IV	Verbal Comprehension	93 (15)	−0.50	0.02	91 (14)	−0.59	0.02	1.19	3.76	0.98	3.42	4.42	0.91
WRAVMA	Drawing	98 (19)	−0.14	0.59	99 (18)	−0.06	0.48	−1.40	4.74	0.98	−3.61	5.99	0.91
BBCS-3:R	School Readiness Composite	94 (19)	−0.38	0.10	93 (18)	−0.39	0.11	0.14	4.80	0.98	−2.38	5.65	0.91
BRIEF-P Parent	Global Executive Composite	52 (14)	0.15	0.73	52 (13)	0.14	0.94	0.23	3.45	0.98	0.90	4.48	0.91

ISD, standard deviation; SE, standard error; FDR, false discovery rate; WPPSI-IV, The Wechsler Preschool & Primary Scale of Intelligence, Fourth Edition; WRAVMA, The Wide Range Assessment of Visual Motor Abilities; BBCS-3:R, Bracken Basic Concept Scale: Receptive – Third Edition, BRIEF-P, The Behavior Rating Inventory of Executive Function – Preschool

^a: Estimated change in score for current HU user compared to patient currently not using HU.

^b: Estimate for effect of current HU use on score after adjusting for BSMSS, social vulnerability index, age at assessment, genotype, sex, and current HU treatment status