Table 1.

Optimal application of decentralized trial design elements across study phases (+)

Phase	Online Recruitment	Electronic Consent (Remote eConsent)	Electronic Consent (On-Site eConsent)	Electronic Patient Education + Engagement	Electronic Clinical Outcome Assessments (eCOAs)	Telehealth	Wearable Sensors	Home Health Visits by Healthcare Professionals	Drug Supply by Mail
Natural History Study/Registry	+	+		+	+	+	+
First in Human/Ph1			+	+	+	+
Phase II/III	+		+	+	+	+	+	+	+
Open Label Extension		+		+	+	+	+	+	+
Post-Approval Observational	+	+		+	+	+	+
Long-Term Followup		+		+	+	+	+