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. 2022 May 25;12(12):6816–6830. doi: 10.1021/acscatal.2c00257

Scheme 1. Epimerization of Sugar Nucleotide Substrates via Transient Oxidation–Reduction.

Scheme 1

Epimerization shown for the conversion of CDP-glucose into CDP-mannose (a) catalyzed by TaCPa2E (the C2 epimerase from T. atlanticus). CDP-paratose (b) is probably the native substrate of TaCPa2E. It is shown for comparison with CDP-glucose.62