Table 1.
Pharmacokinetic parameters for flunixin meglumine and flunixin meglumine compounded with iron dextran determined by noncompartmental analysis in piglets.
| Parameter | Unit | Flunixin meglumine n = 8 |
Flunixin meglumine + Iron dextran n = 8 |
|---|---|---|---|
| AUC0–tlast | h*μg/mL | 18.21 ± 5.03 | 12.70 ± 2.88* |
| AUC0–∞ | h*μg/mL | 18.24 ± 5.03 | 12.72 ± 2.88* |
| t1/2 λz (HM) | h | 3.73 (LL 3.11, UL 4.66) | 3.42 (LL 2.89, UL 4.19) |
| λz (HM) | 1/h | 0.17 (LL 0.14, UL 0.21) | 0.19 (LL 0.16, UL 0.26) |
| CL/F | mL/h/kg | 129.19 ± 36.02 | 182.19 ± 48.65* |
| Cmax | μg/mL | 4.58 ± 0.74 | 3.22 ± 0.66* |
| Tmax | h | 0.57 (LL 0.36, UL 0.89) | 0.68 (LL 0.43, UL 1.07) |
| VD/F | mL/kg | 750.10 ± 287.56 | 919.02 ± 245.44 |
| MRT0–∞ (HM) | h | 3.89 (LL 3.43, UL 4.51) | 3.92 (LL 3.45, UL 4.54) |
AUC0–tlast — Area under the concentration time curve from time zero to last measured concentration; AUC0–∞ — AUC from time zero to infinity; t1/2λz — Elimination half-life; λz — Elimination rate constant; CL/F — Systemic clearance per fraction absorbed; Cmax — Maximum plasma concentration; Tmax — Time to maximal plasma concentration; VD/F — Volume of distribution per fraction absorbed; MRT0–∞ — Mean residence time from time zero to infinity. AUC0–tlast, AUC0–∞, CL/F, Cmax, and VD/F are expressed as mean ± SD. HM — Harmonic mean with 95% CI. Tmax is presented as median with lower and upper range limits.
Versus corresponding reference value (P < 0.05). n — Number of piglets per treatment group; LL — Lower limit; UL — Upper limit.