Figures 3–5.

Virological studies. No significant differences in viral loads in brain were observed between the 2 dose groups at 4 and 7 days postinoculation (dpi). In the high-dose group, viral genomic DNA was found in the brain as early as 2 dpi. Figure 3. Viral load in the brain of SARS-CoV-2-inoculated hACE2-transgenic mice measured by means of viral genomic RNA. Figure 4. Viral load in the brain of SARS-CoV-2-inoculated hACE2-transgenic mice measured by means of viral subgenomic RNA. Figure 5. Viral load in the brain of SARS-CoV-2-inoculated hACE2-transgenic mice measured by means of infectious virus (in cell culture). Each dot represents a single animal. ns, nonsignificant differences. The bars show the mean ± standard deviation.