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. 2022 Jun 6;13:924174. doi: 10.3389/fphar.2022.924174

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Copyright © 2022 Li, Xia, Wu, Yuan, Lu, Huang, Gu, Zheng, You and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of I3C on pro-oxidant stress parameters in myocardial tissue of I/R mice. (A,B) Representative images (A) and quantitative analysis (B) showed that I3C pretreatment (100 mg/kg) prevented the I/R-induced increase in the number of DHE-positive cells in ischemic cardiac tissue (n = 5, **p < 0.01 vs. sham treatment, ##p < 0.01 vs. I/R). (C–E) Quantitative analysis showed that I3C pretreatment prevented the I/R-induced increase in MDA (C), ROS (D), and NO (E) levels in ischemic heart tissue (n = 5, **p < 0.01 vs. sham treatment, ##p < 0.01 vs. I/R). Scale bars: 20 μm. Data are expressed as mean ± SEM.