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. 2022 Jan 29;59(4):602–612. doi: 10.1177/03009858211071016

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 Lficense (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — SARS-CoV-2 infection, nasal mucosa, K18-hACE2-transgenic (Tg) mouse, 3 days post-infection (dpi). (a) There is moderate rhinitis with focally disordered arrangement, necrosis, and sloughing (arrow) of the olfactory epithelium. Hematoxylin and eosin (HE). (b) Abundant viral RNA is detected in the olfactory epithelium (arrowhead) and in the lamina propria (arrow) underlying the olfactory epithelium. In situ hybridization (ISH) for SARS-CoV-2. (c) SARS-CoV-2 nucleocapsid protein is present in neurons of the olfactory bulb (arrow). Dual immunohistochemistry (IHC) for nucleocapsid protein (brown) and olfactory marker protein (red). (d) SARS-CoV-2 nucleocapsid protein is observed in the lamina propria (arrow) underlying the olfactory epithelium. IHC for nucleocapsid protein.

Abbreviations: hACE2, human angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; IHC, immunohistochemistry.