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. 2022 Jan 29;59(4):602–612. doi: 10.1177/03009858211071016

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 Lficense (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figures 4 and 5. — SARS-CoV-2 infection, nasal mucosa, hACE2 Tg mouse, 5 days post-infection. (a) The olfactory epithelium is intact (arrow, inset), and necrosis is not observed. Hematoxylin and eosin. (b) Faint immunolabeling for SARS-CoV-2 nucleocapsid protein is observed in the olfactory epithelium (arrow, inset). (c) and Figure 5. Viral RNA (arrow, Fig. 5) is scattered at the surface of the olfactory epithelium. In situ hybridization for SARS-CoV-2.

Abbreviations: SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; hACE2, human angiotensin-converting enzyme 2.