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. 2022 Jan 29;59(4):602–612. doi: 10.1177/03009858211071016

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 Lficense (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figures 6 and 7. — SARS-CoV-2 infection, nasal mucosa, Syrian hamster, 7 days post-infection. (a) There is disordered arrangement of olfactory epithelial cells (arrow, inset) and inflammatory exudation is observed. Hematoxylin and eosin (HE). (b) SARS-CoV-2 nucleocapsid protein (arrow, inset) is observed in the olfactory epithelium. IHC for nucleocapsid protein. (c) and Figure 7. Massive amount of viral RNA is detected in sloughed epithelial cells in the inflammatory exudate (arrowhead, Fig. 7) and a smaller quantity in the olfactory epithelium (arrow, Fig. 7). In situ hybridization (ISH).

Abbreviations: SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; IHC, immunohistochemistry.