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. 2022 Jan 29;59(4):602–612. doi: 10.1177/03009858211071016

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 Lficense (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figures 8 and 9. — SARS-CoV-2 infection, nasal mucosa, Syrian hamster, 7 days post-infection. (a) Apoptosis is detected in the nuclear layer of sustentacular cells (arrow, inset) in the olfactory epithelium. TUNEL. (b) A large amount of mucus is accumulated on the surface of the olfactory epithelium in the nasal cavity (arrow, inset). Periodic acid-Schiff. (c) and Figure 9. F4/80-positive macrophages are detected in mucous layer (black arrowhead, Fig. 9) and submucosa (arrow, Fig. 9) of the necrotic olfactory epithelium. Immunohistochemistry (IHC) for F4/80.

Abbreviations: SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.