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. 2022 Jun 20;13:263. doi: 10.1186/s13287-022-02947-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Implantation of nerve protectors repopulated with GMSC-derived Schwann-like cells promotes axonal regeneration and remyelination of crush-injured rat sciatic nerves. a Toluidine blue staining of semi-thin sections of the injured nerves from different groups of rats at 4 weeks post-injury and implantation. Scale bars, 20 µm. b Transmission electron microscopy (TEM) of ultrathin sections of the injured sciatic nerves from different groups of rats at 4 weeks post-injury and implantation. Scale bars, 4 µm. c Quantification of the density of myelinated axons (the number of myelinated axons/1000 µm²). d Quantification of the thickness of the myelin sheaths. e Calculation of the G-ratios (the inner axonal diameter/the outer myelinated fiber diameter). Data are shown as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001; ns, no significance. One-way ANOVA with Tukey’s posttest. Abbreviations: NP, nerve protector; NP/GiSCs, nerve protectors repopulated with GMSC-derived Schwann-like cells (GiSC)