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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Exp Neurol. 2020 Sep 25;335:113483. doi: 10.1016/j.expneurol.2020.113483

Figure 1. Experimental set-up.

Figure 1.

(A) Participants were seated in a customized chair during paired corticospinal-motoneuronal stimulation (PCMS) combined with acute intermittent hypoxia (PCMS+AIH) and sham AIH (PCMS+sham-AIH). PCMS was delivered using transcranial magnetic stimulation (TMS) over the hand representation of the primary motor cortex and supramaximal peripheral nerve stimulation (PNS) over the ulnar nerve with 180 pairs of stimuli delivered every 10 s (0.1 Hz). The position of the TMS coil was monitored using a frameless stereotaxic system and electromyographic (EMG) activity was recorded from the first dorsal interosseous (FDI) muscle to record electrophysiological outcomes. AIH was administered by using the Hypoxico Inc. (EVEREST SUMMIT II, New York) and the protocol consisted of 15 cycles of 1 min of inspiring ambient air with 1 min of hypoxic air. (B) Timeline of the experimental procedures. Electrophysiological outcomes were measured before (Baseline) and 30 min after each protocol.