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. 2022 Jun 6;13:901437. doi: 10.3389/fimmu.2022.901437

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Copyright © 2022 Iwasaki, Watanabe, Ito, Fujii, Okuma, Oku, Hirayama, Ohmura, Murata, Murakami, Yoshitomi, Tanaka, Matsuda, Matsuda, Morinobu and Hashimoto

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of single-cell data and a deconvolution analysis of the IFN signature. (A) Type I IFN scores for each cell subtype are shown. (B) Fold changes (after/before treatment) in the mean expression of type II IFN-related genes are shown according to each cell subtype. A heatmap of estimated expression in cells positive for CD8 (C) and CD4 (D). The estimated expression of each gene was standardized across all samples, and Z scores were shown. * stands for p < 0.05 by the Mann-Whitney U test. CD4, CD4-positive cells; CD8, CD8-positive cells; B, B cells; DC, Dendritic cells; NK, Natural killer cells.