. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: Mutat Res Rev Mutat Res. 2021 Dec 20;789:108409. doi: 10.1016/j.mrrev.2021.108409

Table 1.

Identification of types of mutations induced by Acr or BPDE in the CpG methylated and unmethylated supF gene compared with types of mutations that occur at CpG mutational hotspots in the TP53 gene in tobacco smoke–related lung cancer (Adapted from Wang et al.(97)).

Mutations at CpG site	Control		Acr^b		BPDE^c		p53^d
Mutations at CpG site	UM^a	M^a	UM	M	UM	M
G to T	2 (40%)	1 (6%)	9 (36%)	15 (54%)	10 (48%)	20 (71%)	296 (49%)
G to A	2 (40%)	17 (94%)	7 (28%)	11 (39%)	1 (4%)	3 (11%)	219 (36%)
Others^e	1 (20%)	0 (0%)	9 (36%)	2 (7%)	10 (48%)	5 (18%)	96 (15%)

UM: unmethylated supF; M: methylated supF.

Acr: 0.5 mM at 37°C for 24 h.

BPDE: 2μM at 37°C for 1 h.

CpG sites at codons 157, 158, 175, 245, 248, 273 and 282 of p53 in TS-related lung cancer.

Other types of mutations including G to C, insertion, deletion or tandem mutations.