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(A) Confocal images of eIF2B bodies in (i) S. cerevisiae strain yMK880 (eIF2Bγ-GFP) (ii) a human U373 astrocytoma cell overexpressing eIF2Bε-GFP. (B) Schematic representation of decameric eIF2B(αβδγε)2 and eIF2B(βδγε) tetrameric and eIF2B(γε) heterodimeric subcomplexes that have been identified in yeast and mammalian cells localising to eIF2B bodies.
