Table 1. Biological processes of eIF2B protein–protein interactors.
| Go term ID | GO term annotation | Number of genes involved per eIF2B subunit | ||||
|---|---|---|---|---|---|---|
| eIF2Bα | eIF2Bβ | eIF2Bγ | eIF2Bδ | eIF2Bε | ||
| GO:0007165 | Signal transduction | 40 | 37 | 39 | 48 | 46 |
| GO:0006810 | Transport | 34 | 38 | 31 | 30 | 43 |
| GO:0048856 | Anatomical structure development | 40 | 42 | 37 | 43 | 42 |
| GO:0002376 | Immune system process | 28 | 28 | 25 | 27 | 34 |
| GO:0006950 | Response to stress | 35 | 26 | 36 | 28 | 33 |
| GO:0030154 | Cell differentiation | 35 | 30 | 24 | 33 | 30 |
| GO:0034641 | Cellular nitrogen compound metabolic process | 33 | 41 | 32 | 28 | 27 |
| GO:0009058 | Biosynthetic process | 23 | 33 | 24 | 20 | 27 |
| GO:0022607 | Cellular component assembly | 14 | 22 | 17 | 16 | 25 |
| GO:0042592 | Homeostatic process | 16 | 20 | 17 | 18 | 24 |
| GO:0006464 | Cellular protein modification process | 18 | 22 | 17 | 19 | 23 |
| GO:0040011 | Locomotion | 12 | 14 | 10 | 14 | 21 |
| GO:0015031 | Protein transport | 20 | 18 | 12 | 13 | 19 |
| GO:0016192 | Vesicle-mediated transport | 13 | 16 | 11 | 11 | 19 |
| GO:0065003 | Protein-containing complex assembly | 11 | 16 | 13 | 11 | 18 |
| GO:0009056 | Catabolic process | 17 | 17 | 10 | 11 | 16 |
| GO:0048870 | Cell motility | 9 | 10 | 8 | 11 | 16 |
| GO:0007155 | Cell adhesion | 7 | 11 | 8 | 12 | 15 |
| GO:0007267 | Cell–cell signalling | 11 | 11 | 11 | 12 | 15 |
| GO:0008219 | Cell death | 9 | 9 | 9 | 9 | 15 |
| GO:0044281 | Small molecule metabolic process | 6 | 12 | 12 | 8 | 14 |
| GO:0055085 | Transmembrane transport | 8 | 11 | 9 | 9 | 13 |
| GO:0044403 | Symbiotic process | 16 | 12 | 11 | 10 | 12 |
| GO:0061024 | Membrane organisation | 11 | 13 | 11 | 9 | 12 |
| GO:0006412 | Translation | 13 | 14 | 9 | 7 | 11 |
| GO:0006629 | Lipid metabolic process | 6 | 8 | 6 | 5 | 11 |
| GO:0000003 | Reproduction | 15 | 13 | 12 | 10 | 10 |
| GO:0007049 | Cell cycle | 8 | 7 | 6 | 4 | 10 |
| GO:0008283 | Cell population proliferation | 4 | 7 | 7 | 6 | 9 |
| GO:0050877 | Nervous system process | 5 | 6 | 7 | 6 | 9 |
| GO:0007010 | Cytoskeleton organisation | 2 | 2 | 4 | 4 | 9 |
| GO:0051276 | Chromosome organisation | 6 | 11 | 10 | 9 | 8 |
| GO:0051301 | Cell division | 4 | 2 | 3 | 2 | 8 |
| GO:0000902 | Cell morphogenesis | 7 | 10 | 4 | 7 | 7 |
| GO:0006259 | DNA metabolic process | 4 | 8 | 7 | 6 | 7 |
| GO:0000278 | Mitotic cell cycle | 4 | 2 | 4 | 2 | 6 |
| GO:0007568 | Aging | 4 | 4 | 3 | 4 | 5 |
| GO:0006914 | Autophagy | 5 | 5 | 4 | 3 | 5 |
| GO:0003013 | Circulatory system process | 6 | 4 | 5 | 5 | 4 |
| GO:0034655 | Nucleobase-containing compound catabolic process | 5 | 7 | 2 | 5 | 4 |
| GO:0022618 | Ribonucleoprotein complex assembly | 3 | 6 | 4 | 2 | 4 |
| GO:0007034 | Vacuolar transport | 3 | 1 | 2 | 1 | 4 |
| GO:0007005 | Mitochondrion organisation | 3 | 2 | 4 | 0 | 4 |
| GO:0009790 | Embryo development | 5 | 7 | 7 | 8 | 3 |
| GO:0006605 | Protein targeting | 7 | 7 | 3 | 4 | 3 |
| GO:0006790 | Sulfur compound metabolic process | 3 | 3 | 1 | 2 | 3 |
| GO:0021700 | Developmental maturation | 2 | 2 | 0 | 2 | 3 |
| GO:0007059 | Chromosome segregation | 1 | 1 | 2 | 1 | 3 |
| GO:0042254 | Ribosome biogenesis | 5 | 4 | 2 | 8 | 2 |
| GO:0006397 | mRNA processing | 6 | 9 | 6 | 5 | 2 |
| GO:0048646 | Anatomical structure formation involved in morphogenesis | 1 | 3 | 2 | 5 | 2 |
| GO:0006457 | Protein folding | 1 | 2 | 1 | 2 | 2 |
| GO:0034330 | Cell junction organisation | 1 | 2 | 2 | 2 | 2 |
| GO:0040007 | Growth | 2 | 1 | 0 | 2 | 2 |
| GO:0006091 | Generation of precursor metabolites and energy | 1 | 2 | 2 | 1 | 2 |
| GO:0006913 | Nucleocytoplasmic transport | 2 | 2 | 2 | 1 | 2 |
| GO:0030705 | Cytoskeleton-dependent intracellular transport | 1 | 3 | 2 | 1 | 2 |
| GO:0140014 | Mitotic nuclear division | 0 | 0 | 1 | 0 | 2 |
| GO:0051186 | Cofactor metabolic process | 2 | 2 | 2 | 2 | 1 |
| GO:0005975 | Carbohydrate metabolic process | 0 | 0 | 0 | 1 | 1 |
| GO:0007009 | Plasma membrane organisation | 1 | 2 | 0 | 1 | 1 |
| GO:0006091 | Extracellular matrix organisation | 0 | 1 | 0 | 0 | 1 |
| GO:0019748 | Secondary metabolic process | 1 | 0 | 0 | 0 | 1 |
| GO:0043473 | Pigmentation | 0 | 1 | 0 | 0 | 1 |
| GO:0051604 | Protein maturation | 1 | 0 | 0 | 1 | 0 |
| GO:0006399 | tRNA metabolic process | 1 | 3 | 0 | 0 | 0 |
| GO:0006520 | Cellular amino acid metabolic process | 4 | 2 | 2 | 0 | 0 |
Identification of genes involved in protein–protein interactions was performed and curated by BioGRID (release 4.4.201). Gene ontology classification was performed using GOnet (DICE database, build January 2020). The whole human repository annotation was used as reference set.