TABLE 2.
Adjusted means (95% CIs) of blood glucose and log-transformed disposition indices across increasing VFA quartiles
| VFA (cm2) |
P for linear trend | ||||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
|
| |||||
| Men | |||||
| Age-adjusted means | |||||
| Fasting plasma glucose (mmol/L) | 5.67 (5.64–5.71) | 5.79 (5.76–5.83) | 5.88 (5.84–5.91) | 6.02 (5.99–6.06) | < 0.001 |
| 30-min plasma glucose (mmol/L) | 9.85 (9.75–9.95) | 10.0 (9.92–10.1) | 10.2 (10.1–10.3) | 10.6 (10.5–10.6) | < 0.001 |
| 2-h plasma glucose (mmol/L) | 6.57 (6.44–6.70) | 7.10 (6.97–7.23) | 7.73 (7.60–7.86) | 8.30 (8.17–8.43) | < 0.001 |
| lgDIearly | 0.90 (0.88–0.92) | 0.82 (0.80–0.84) | 0.75 (0.73–0.76) | 0.68 (0.66–0.70) | < 0.001 |
| lgDI1st | 2.63 (2.60–2.65) | 2.58 (2.56–2.60) | 2.54 (2.52–2.56) | 2.50 (2.48–2.52) | < 0.001 |
| lgDI2nd | 2.21 (2.19–2.22) | 2.13 (2.11–2.14) | 2.07 (2.06–2.08) | 2.01 (2.00–2.03) | < 0.001 |
| Multivariable-adjusted meansa | |||||
| Fasting plasma glucose (mmol/L) | 5.77 (5.73–5.81) | 5.81 (5.77–5.84) | 5.85 (5.81–5.89) | 5.94 (5.89–5.98) | < 0.001 |
| 30-min plasma glucose (mmol/L) | 10.0 (9.91–10.1) | 10.1 (9.95–10.1) | 10.2 (10.1–10.3) | 10.4 (10.3–10.5) | < 0.001 |
| 2-h plasma glucose (mmol/L) | 6.77 (6.61–6.92) | 7.12 (6.99–7.25) | 7.67 (7.54–7.80) | 8.15 (7.99–8.30) | < 0.001 |
| lgDIearly | 0.85 (0.83–0.87) | 0.81 (0.79–0.83) | 0.76 (0.74–0.78) | 0.72 (0.70–0.75) | < 0.001 |
| lgDI1st | 2.61 (2.58–2.63) | 2.58 (2.56–2.60) | 2.55 (2.53–2.57) | 2.52 (2.49–2.54) | < 0.001 |
| lgDI2nd | 2.16 (2.15–2.18) | 2.12 (2.11–2.13) | 2.08 (2.07–2.10) | 2.05 (2.04–2.07) | < 0.001 |
| Women | |||||
| Age-adjusted means | |||||
| Fasting plasma glucose (mmol/L) | 5.63 (5.60–5.67) | 5.76 (5.72–5.79) | 5.86 (5.83–5.89) | 6.00 (5.96–6.03) | < 0.001 |
| 30-min plasma glucose (mmol/L) | 9.64 (9.55–9.72) | 9.90 (9.81–9.98) | 10.2 (10.1–10.3) | 10.4 (10.3–10.5) | < 0.001 |
| 2-h plasma glucose (mmol/L) | 7.02 (6.91–7.14) | 7.72 (7.61–7.83) | 8.26 (8.15–8.38) | 9.01 (8.90–9.13) | < 0.001 |
| lgDIearly | 0.89 (0.88–0.91) | 0.81 (0.79–0.82) | 0.74 (0.72–0.75) | 0.67 (0.65–0.69) | < 0.001 |
| lgDI1st | 2.65 (2.64–2.67) | 2.60 (2.58–2.61) | 2.55 (2.54–2.57) | 2.52 (2.51–2.54) | < 0.001 |
| lgDI2nd | 2.18 (2.17–2.19) | 2.11 (2.10–2.12) | 2.05 (2.04–2.07) | 2.01 (2.00–2.02) | < 0.001 |
| Multivariable-adjusted meansa | |||||
| Fasting plasma glucose (mmol/L) | 5.68 (5.65–5.72) | 5.77 (5.74–5.81) | 5.85 (5.82–5.88) | 5.94 (5.90–5.98) | < 0.001 |
| 30-min plasma glucose (mmol/L) | 9.72 (9.62–9.82) | 9.93 (9.84–10.0) | 10.2 (10.1–10.3) | 10.3 (10.2–10.4) | < 0.001 |
| 2-h plasma glucose (mmol/L) | 7.28 (7.15–7.41) | 7.80 (7.69–7.92) | 8.20 (8.09–8.32) | 8.74 (8.60–8.87) | < 0.001 |
| lgDIearly | 0.86 (0.84–0.88) | 0.80 (0.78–0.81) | 0.75 (0.73–0.76) | 0.71 (0.69–0.73) | < 0.001 |
| lgDI1st | 2.64 (2.62–2.66) | 2.59 (2.58–2.61) | 2.56 (2.54–2.57) | 2.54 (2.52–2.56) | < 0.001 |
| lgDI2nd | 2.15 (2.14–2.16) | 2.10 (2.09–2.11) | 2.06 (2.05–2.07) | 2.04 (2.02–2.05) | < 0.001 |
Cut points of VFA (cm2) are 83.5, 117.8, and 155.5 in men and 78.4, 103.3, and 131.8 in women. Linear trend test tested by linear regression.
a
Adjusted for age, BMI, and subcutaneous fat area.
DIearly, early-phase disposition index; DI1st, first-phase disposition index; DI2nd, second-phase disposition index; lg, log-transformed; VFA, visceral fat area.