Table 3.

Frailty metabolic phenotypes

Anorexic malnourished (AM)	Sarcopenic obese (S0)
Poor appetite, reduced energy intake and weight loss	Good appetite, increased energy intake and weight gain
Reduced skeletal muscle mass and visceral fat	Reduced skeletal muscle mass and increased visceral fat
Reduced insulin resistance	Increased insulin resistance
Tendency to hypoglycaemia	Tendency to hyperglycaemia
Diabetes course is regressive	Diabetes course is progressive
Progressive deintensification of hypoglycaemic therapy	Progressive intensification of hypoglycaemic agents
Weight limiting hypoglycaemic agents are not suitable	Weight limiting hypoglycaemic agents are suitable