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Emodin suppresses tumor growth and promotes the polarization of M2 to M1 macrophages in HCC in vivo. (a) The representative image, (b) growth curve, and (c) weight of xenografts collected from HepG2, HepG2/M2, and HepG2/M2+ emodin groups. (d) The protein expression of CD206, iNOS, PCNA, TGF-β1, and p-Akt in xenografts was detected by Western blot. ***P < 0.005, vs. HepG2 group; ###P < 0.005, vs. HepG2/M2 group.
