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. 2022 Mar 16;13(3):7904–7918. doi: 10.1080/21655979.2022.2052673

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — SK reinforces its anti-tumoral effects by downregulating PYCR1 in HCC Cells. a, b, c. Western blotting and RT-PCR detect protein and mRNA levels of PYCR1 in SNU-449and Hep-3B cells treated with SK (0, 1, and 3 μM) (0, 4, and 6 μM) for 48 h. d. The activity of each group in SNU-449and Hep-3B cells was detected by CCK8 assay. e. Colony formation assay was used to detect the growth of SNU-449and Hep-3B cells. f. Wound healing assays were performed on SNU-449and Hep-3B cells. The right panel displays a histogram of the results. Scale bar: 200 μm. g. Migration and invasion assay was carried out on SNU-449and Hep-3B cells. Scale bar: 50 μ m. *P < 0.05 for SK or siPYCR1vs the control; ##p < 0.01 for SK +siPYCR1 vs SK only.