Table 2.

Inflammatory markers altered in ovaries and uterus during inflammation

S.No.	Inflammation Model	Findings of the study	References
1.	Autoimmune ovarian disease model	Up-regulation of proinflammatory markers such as IL-1, TNF-α, and IFN-γ	[207]
2.	Ovarian biopsies from women with premature autoimmune ovarian failure.	Ovarian granulosa cells had ectopic expression of MHC-II in the site of inflammation.	[208]
3.	Autoimmune ovarian disease model (Cynomolgus macaques)	Co-localization of T cell clusters with MHC-II+ macrophages in the ovarian interstitium.	[205]
4.	Females with premature ovarian insufficiency	Increased level of chemokines such as MIP-1α, IL-8, eotaxin-1 and interferon inducible protein-10 as well as lymphangiogenic factor VEGF-D in follicular fluid.	[209]
5.	Endometriosis	Elevated levels of intercellular adhesion molecule-1, insulin-like growth factor-I, IL-1, IL-6, IL-8, IL-12, MCP-1, MIP-1α, RANTES, eotaxin, VEGF and TNFα were associated with endometriosis.	(Explained in detail in the cited reviews) [211,213]