. 2022 Apr;11(1):89–101. doi: 10.52547/rbmb.11.1.89

Table 4.

Haplotypes distribution of MTHFR C677T, MTHFR A1298C and MTR A2756G in breast cancer patients and controls.

MTHFR C677T	MTHFR A1298C	MTR A2756G	Cases N (100)	Controls n (60)	OR/RS (95% CI)	p value
CC	AA	AA	1 (1%)	16 (26.7%)	1.00 (Reference)
		AG	5 (5%)	6 (10%)	13.333 (1.280 - 138.845)	0.013 *
		GG	1 (1%)	0 (0%)	17.000 (2.539 - 113.824)	0.004 ^**
	AC	AA	6 (6%)	12 (20%)	8.000 (0.847 - 75.555)	0.042 ^NS
		AG	1 (1%)	2 (3.3%)	8.000 (0.347 - 184.364)	0.144 ^NS
		GG	0 (0%)	0 (0%)	----------	--------
	CC	AA	4 (4%)	4 (6.7%)	16.000 (1.381 - 185.405)	0.010 ^**
		AG	0 (0%)	0 (0%)	----------	--------
		GG	0 (0%)	0 (0%)	----------	--------
CT	AA	AA	2 (2%)	7 (11.7%)	4.571 (0.354 - 59.106)	0.215^NS
		AG	2 (2%)	3 (5%)	10.667 (0.718 - 158.505)	0.050 *
		GG	0 (0%)	0 (0%)	----------	--------
	AC	AA	3 (3%)	9 (15%)	5.333 (0.481 - 59.144)	0.141 ^NS
		AG	20 (20%)	1 (1.7%)	320.000 (18.534 - 5524.894)	0.001 ^**
		GG	2 (2%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**
	CC	AA	1 (1%)	0 (0%)	17.000 (2.539 - 113.824)	0.004 ^**
		AG	19 (19%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**
		GG	6 (6%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**
TT	AA	AA	0 (0%)	0 (0%)	----------	--------
		AG	0 (0%)	0 (0%)	----------	--------
		GG	0 (0%)	0 (0%)	----------	--------
	AC	AA	0 (0%)	0 (0%)	----------	--------
		AG	5 (5%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**
		GG	6 (6%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**
	CC	AA	1 (1%)	0 (0%)	17.000 (2.539 - 113.824)	0.004 ^**
		AG	6 (6%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**
		GG	9 (9%)	0 (0%)	17.000 (2.539 - 113.824)	0.001 ^**

OR: odds ratio, CI: confidence interval,

^NS

(Not significant)

^**

highly significant.