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. 2022 Feb 9;48(4):e12793. doi: 10.1111/nan.12793

FIGURE 1.

FIGURE 1

HnRNP K mislocalisation in neurons of the dentate nucleus. (A) Representative (×60) images of normal, nuclear localisation of hnRNP K in neurons of the dentate nucleus within three control subjects. (B) Representative images of abnormal, mislocalised neuronal staining of hnRNP K within three FTLD‐TDP A cases exhibiting distinct nuclear depletion and cytoplasmic puncta accumulation. (C) Representative images of hnRNP K mislocalisation in three Alzheimer's disease (AD) cases. Purple arrows indicate neurons with clear hnRNP K nuclear depletion. Scale bars are as indicated in first image. (D) Quantitation of hnRNP K mislocalisation expressed as proportion (%) of neurons with hnRNP K mislocalisation in age‐matched control (n = 21), FTLD‐TDP A (n = 18) and AD (n = 17) cohorts. (E) Equivalent quantitation and analysis expressing hnRNP K mislocalisation as number of neurons per image exhibiting mislocalisation. Individual data points indicate mean data from distinct cases. Error bars show mean ± SD. Ordinary one‐way ANOVA with Tukey's post hoc test; * p < 0.05, ** p < 0.01, *** p < 0.001. (F) HnRNP K mislocalisation in control subjects positively correlates with age at death (Pearson's r = 0.433, p = 0.011)