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Schematic representation of the prime editing tool. The editing system is attached to complementary target DNA by pegRNA, after which nCas9 produces a nick in the 3ʹ-5ʹ strand. Subsequently, reverse transcriptase uses the cut strand as a primer to synthesize the new edited strand from the pegRNA template. The edited strand hybridizes with the unedited one, which is preferentially repaired based on the edit. Modified from Marzec and Hensel.111
