Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 16;15:3547–3560. doi: 10.2147/JIR.S365545

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Dong et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Histone deacetylase 4 (HDAC4) deletion induced diverse changes in osteoarthritis (OA)-related genes in mice. (A–C) HDAC4 knockout led to significant differences in the relative mRNA expression of OA-related genes between the AggH-Tam and AggH-Oil groups in 8-month-old. Data are shown as the mean ± SD. The results were normalized to 18S mRNA. *P < 0.05, **p < 0.01, ***p < 0.001. (D) Matrix metalloprotease 13 (MMP-13), type II collagen, aggrecan, Runt-related transcription factor 2 (Runx2), SRY-box transcription factor 9 (Sox9), type X collagen, Indian hedgehog (Ihh), and parathyroid hormone-related protein (PTHrP) immunochemical staining of the different groups. And the relative locations were indicated by the red frame in the bottom right corner of each picture. Scale bars: 50 μm.