Table 3.
Association of glucose and glucose-corrected plasma sodium fluctuations with death and neurodevelopmental outcomes, without and with adjustment for gestational age and SNAP score.
| Glucose | Plasma sodium | Glucose-corrected plasma sodium | ||||
|---|---|---|---|---|---|---|
| B (95% CI) | p value | B (95% CI) | p value | B (95% CI) | p value | |
| No adjustment | ||||||
| Death at 18 months’ CA or neurodevelopmental impairment |
2.57 (1.29, 3.84) |
0.001 |
3.33 (1.45, 5.21) |
0.001 |
3.19 (1.24, 5.14) |
0.002 |
| Adjustment for gestational age | ||||||
| Death at 18 months’ CA or neurodevelopmental impairment |
1.74 (0.49, 2.99) |
0.007 |
2.28 (0.40, 4.15) |
0.019 |
2.10 (0.16, 4.04) |
0.036 |
| Adjustment for SNAP score | ||||||
| Death at 18 months’ CA or neurodevelopmental impairment |
2.37 (0.90, 3.84) |
0.002 |
2.92 (0.84, 5.00) |
0.007 |
2.84 (0.70, 4.98) |
0.011 |
| Adjustment for NSAID use | ||||||
| Death at 18 months’ CA or neurodevelopmental impairment |
2.39 (0.94, 3.84) |
0.002 |
2.45 (0.43, 4.47) |
0.019 |
1.97 (−0.10, 4.04) |
0.065 |
| Adjustment for all covariatesa | ||||||
| Death at 18 months’ CA or neurodevelopmental impairment |
1.91 (0.35, 3.46) |
0.017 |
2.28 (0.01, 4.56) |
0.049 |
2.03 (−0.30, 4.37) |
0.087 |
Sodium and glucose fluctuations were defined by the difference between the maximal value and the minimal value recorded for each individual within the time period. Results are shown as coefficients B with 95% confidence interval (CI) calculated using linear regression.
Adj for GA adjusted for gestational age.
aAdjustment for gestational age, SNAP score, and NSAID use.