Table 1:

Summary of included studies (n=4).

Study, recruitment years	Population/Eligibility	No. of screening rounds	Psychosocial Outcome (Instrument)
Randomized Controlled Trials
DLCST16, 17, 2004–2006	• Age: 50–70 years • Current or Former Smokers (quit after age 50 and <10 years prior) • ≥20 pack-years	• 5	• Anxiety, sense of dejection, negative impact on behavior and sleep, busy to take mind of things, less interest in sex (COS, COS-LC) • Focus on airway symptoms, introvert, stigmatization, harm of smoking, self-blame (COS-LC) • Redeemed AD or AX prescriptions
NELSON18–20, 1st phase: 2003-NR 2nd phase: October 2005-NR	• Age: 50–75 years • Current Smokers or Former Smokers (≤10 years prior) • >15 cig/day for >25 years or >10 cig/day for >30 years	• 3	• Health-related quality of life (EQ-5D, SF-12) • Anxiety (STAI-6) • Distress (IES)
Cohort
PLuSS21, Jan 2002- Apr 2005	• Age: 50–79 years • Current Smokers or Former smokers (≤10 years prior) • ≥1/2 pack/day for ≥25 years	• 2	• Anxiety (STAI) • Fear (PCQ)

Abbreviations: AD = antidepressant, AX = anxiolytic, COS-LC = Consequences of Screening in Lung Cancer, CT = computed tomography, DLCST = Danish Lung Cancer Screening Trial, EQ-5D = EuroQol questionnaire, IES = Impact of Event Scale, Mayo = Mayo Clinic Lung Cancer Genetic Epidemiology Registry, NA = not applicable, NELSON = NEderlands Leuvens Longkanker Screenings Onderzoek, No. = number, NR= not reported, PCQ = Psychological Consequences Questionnaire, PLuSS = Pittsburgh Lung Screening Study, SF-12 = 12-item Short Form, STAI = Full version Spielberger State-Trait Anxiety Inventory, STAI-6 = Six-item Spielberger State-Trait Anxiety Inventory