eTable 2.

Quality Ratings for Studies reporting on the Association of LDCT Screening Findings with Patient-Centered Outcomes

Trial, Year	Did the study attempt to enroll a random sample or consecutive patients meeting inclusion criteria (inception cohort)?	Were the groups comparable at baseline?	Did the study use accurate methods for ascertaining exposures, potential confounders, and outcomes?	Were outcome assessors and/or data analysts blinded to treatment?	Did the article report attrition?	Did the study perform appropriate statistical analyses on potential confounders?	Is there important differential loss to follow-up or overall high loss to follow-up?	Were outcomes pre-specified and defined, and ascertained using accurate methods?	Quality
NELSON, 200816	Yes	NR	Yes	No	Yes	No	No	Yes	Fair
NELSON, 201017	Yes	Yes	Yes	No	Yes	Yes	NR	Yes	Fair
PLuSS, 200819	Yes	No	Yes	No	Yes	Yes	No	Yes	Fair

Abbreviations: DLCST = Danish Lung Cancer Screening Trial; LDCT = low-dose computed tomography; NELSON = Nederlands-Leuvens Longkanker Screenings Onderzoek; NR = Not reported; PLuSS = Pittsburgh Lung Screening Study