3.11. Analysis.
Comparison 3 Faecal incontinence: crossover trials, Outcome 11 Anorectal manometry.
| Anorectal manometry | ||||||||
|---|---|---|---|---|---|---|---|---|
| Study | Group | Measure | Patients | Baseline | 'Off' period | 'On' period | Follow‐up | Notes |
| Maximal resting pressure (cm H20) | ||||||||
| Leroi 2005# | Group of 19 who chose 'on' following the crossover period | Median (range) | Baseline: 19 'Off 'period: 13 'On' period: 17 Follow‐up: 18 | 40 (12 to 109) | 37 (26 to 100) | 50 (27 to 155) | 60 (30 to 96) | P < 0.05: 'on' period versus baseline; follow‐up versus baseline; 'off' period versus follow‐up |
| Leroi 2005# | Group of 5 who chose 'off' following the crossover period | Median (range) | Baseline: 5 'Off' period: 5 'On' period: 5 Follow‐up: 5 | 40 (20 to 90) | 50 (39 to 98) | 64 (37 to 98) | 50 (31 to 100) | |
| Sørensen 2010# | Mean (95% CI for mean) | 7 | 106.2 (71.1‐141.4) | 84.2 (70.4‐98.3) | ||||
| Sørensen 2010# | ||||||||
| Tjandra 2008 | Control | Mean±SD | 60 | 42.4±15.2 | Only performed at baseline. | |||
| Tjandra 2008 | SNS | Mean±SD | 53 | 40.4±15.9 | 40.9±21.9 | P > 0.05 at all time points compared with baseline. Follow‐up was at 12 months. | ||
| Vaizey 2000# | Mean (range) | 2 | 38 (35 and 40) | 43 (35 and 50) | 58 (45 and 70) | |||
| Vaizey 2000# | ||||||||
| Maximal squeeze pressure (cm H20) | ||||||||
| Leroi 2005# | Group of 19 who chose 'on' following the crossover period | Median (range) | Baseline: 19 'Off' period: 13 'On' period: 17 Follow‐up: 19 | 30 (0 to 270) | 49 (10 to 98) | 53 (6 to 326) | 50 (0 to 213) | P < 0.05: follow‐up versus baseline |
| Leroi 2005# | Group of 5 who chose 'off' following the crossover period | Median (range) | Baseline: 5 'Off' period: 5 'On' period: 5 Follow‐up: 5 | 30 (23 to 90) | 54 (37 to 110) | 30 (21 to 90) | 30 (20 to 140) | |
| Sørensen 2010# | Mean (95% CI for mean) | 7 | 223.0 (153.7 to 292.4) | 223.0 (159.1 to 287.0) | ||||
| Sørensen 2010# | ||||||||
| Tjandra 2008 | Control group | Mean±SD | 60 | 88.5±42.6 | Only performed at baseline. | |||
| Tjandra 2008 | SNS group | Mean±SD | 53 | 83.2±39.6 | 90.2±54.9 | P > 0.05 at all time points compared with baseline. Follow‐up was at 12 months. | ||
| Vaizey 2000# | Mean (range) | 2 | 100 (80 and 120) | 65 (60 and 70) | 95 (90 and 100) | |||
| Vaizey 2000# | ||||||||
| Squeeze pressure duration (seconds) | ||||||||
| Leroi 2005# | Group of 19 who chose 'on' following the crossover period | Median (range) | Baseline: 19 'Off' period: 13 'On' period: 17 Follow‐up: 19 | 15 (0 to 45) | 21 (4 to 32) | 18 (6 to 92) | 22 (0 to 110) | |
| Leroi 2005# | Group of 5 who chose 'off' following the crossover period | Median (range) | Baseline: 5 'Off' period: 5 'On' period: 5 Follow‐up: 5 | 20 (5 to 28) | 40 (5 to 40) | 32 (23 to 38) | 25 (4 to 40) | |
| Rectal volume sensation ‐ threshold (ml) | ||||||||
| Leroi 2005# | Group of 19 who chose 'on' following the crossover period | Median (range) | Baseline: 17 Follow‐up: 18 | 25 (10 to 120) | Not reported | Not reported | 30 (10 to 120) | |
| Leroi 2005# | Group of 5 who chose 'off' following the crossover period | Median (range) | Baseline: 5 Follow‐up: 5 | 10 (10 to 40) | Not reported | Not reported | 10 (10 to 50) | |
| Sørensen 2010# | Mean (95% CI for mean) | 7 | 50.0 (34.6 to 65.4) | 27.1 (17.8 to 36.4) | ||||
| Sørensen 2010# | ||||||||
| Vaizey 2000# | Mean (range) | 2 | 45 (both 45) | 38 (25 and 50) | 68 (45 and 90) | |||
| Vaizey 2000# | ||||||||
| Rectal volume sensation ‐ urge (ml) | ||||||||
| Sørensen 2010# | Mean (95% CI for mean) | 7 | 82.9 (64.8 to 101) | 60 (48.7 to 71.3) | ||||
| Sørensen 2010# | ||||||||
| Vaizey 2000# | Mean (range) | 2 | 68 (65 and 70) | 85 (70 and 100) | 103 (85 and 120) | |||
| Vaizey 2000# | ||||||||
| Rectal volume sensation ‐ maximal tolerated (ml) | ||||||||
| Leroi 2005# | Group of 19 who chose 'on' following the crossover period | Median (range) | Baseline: 17 Follow‐up: 17 | 185 (80 to 350) | Not reported | Not reported | 170 (40 to 275) | |
| Leroi 2005# | Group of 5 who chose 'off' following the crossover period | Median (range) | Baseline: 5 Follow‐up: 5 | 200 (80 to 300) | Not reported | Not reported | 195 (100 to 300) | |
| Sørensen 2010# | Mean (95% CI for mean) | 7 | 124 (106 to 142) | 124 (82.4 to 165.6) | ||||
| Sørensen 2010# | ||||||||
| Vaizey 2000# | Mean (range) | 2 | 118 (95 and 140) | 135 (120 and 150) | 140 (130 and 150) | |||
| Vaizey 2000# | ||||||||
| Rectal volume sensation ‐ constant sensation volume (ml) | ||||||||
| Leroi 2005# | Group of 19 who chose 'on' following the crossover period | Median (range) | Baseline: 17 Follow‐up: 18 | 100 (40 to 230) | Not reported | Not reported | 85 (30 to 300) | |
| Leroi 2005# | Group of 5 who chose 'off' following the crossover period | Median (range) | Baseline: 5 Follow‐up: 5 | 50 (20 to 90) | Not reported | Not reported | 50 (20 to 95) | |