Comparison 4. Constipation.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Bowel movements per week			Other data	No numeric data
2 Time with abdominal pain and bloating (%)			Other data	No numeric data
3 Wexner Constipation Score			Other data	No numeric data
4 Symptom Analogue Score			Other data	No numeric data
5 Anorectal manometry			Other data	No numeric data
5.1 Maximal resting pressure (cm H₂0)			Other data	No numeric data
5.2 Maximal squeeze pressure (cm H₂0)			Other data	No numeric data
5.3 Rectal volume sensation ‐ threshold (ml air)			Other data	No numeric data
5.4 Rectal volume sensation ‐ urge (ml air)			Other data	No numeric data
5.5 Rectal volume sensation ‐ maximal tolerated (ml air)			Other data	No numeric data
6 Stool frequency (per week)			Other data	No numeric data
7 Pain score (weekly average)			Other data	No numeric data
8 Bloating score (weekly average)			Other data	No numeric data
9 Quality of life ‐ SF36			Other data	No numeric data
10 Adverse events			Other data	No numeric data