Anorectal manometry
Study	Group	Measure	Patients	Baseline	'Off' period	'On' period	Follow‐up	Notes
Maximal resting pressure (cm H20)
Leroi 2005#	Group of 19 who chose 'on' following the crossover period	Median (range)	Baseline: 19 'Off 'period: 13 'On' period: 17 Follow‐up: 18	40 (12 to 109)	37 (26 to 100)	50 (27 to 155)	60 (30 to 96)	P < 0.05: 'on' period versus baseline; follow‐up versus baseline; 'off' period versus follow‐up
Leroi 2005#	Group of 5 who chose 'off' following the crossover period	Median (range)	Baseline: 5 'Off' period: 5 'On' period: 5 Follow‐up: 5	40 (20 to 90)	50 (39 to 98)	64 (37 to 98)	50 (31 to 100)
Sørensen 2010#		Mean (95% CI for mean)	7		106.2 (71.1‐141.4)	84.2 (70.4‐98.3)
Sørensen 2010#
Tjandra 2008	Control	Mean±SD	60	42.4±15.2				Only performed at baseline.
Tjandra 2008	SNS	Mean±SD	53	40.4±15.9			40.9±21.9	P > 0.05 at all time points compared with baseline. Follow‐up was at 12 months.
Vaizey 2000#		Mean (range)	2	38 (35 and 40)	43 (35 and 50)	58 (45 and 70)
Vaizey 2000#
Maximal squeeze pressure (cm H20)
Leroi 2005#	Group of 19 who chose 'on' following the crossover period	Median (range)	Baseline: 19 'Off' period: 13 'On' period: 17 Follow‐up: 19	30 (0 to 270)	49 (10 to 98)	53 (6 to 326)	50 (0 to 213)	P < 0.05: follow‐up versus baseline
Leroi 2005#	Group of 5 who chose 'off' following the crossover period	Median (range)	Baseline: 5 'Off' period: 5 'On' period: 5 Follow‐up: 5	30 (23 to 90)	54 (37 to 110)	30 (21 to 90)	30 (20 to 140)
Sørensen 2010#		Mean (95% CI for mean)	7		223.0 (153.7 to 292.4)	223.0 (159.1 to 287.0)
Sørensen 2010#
Tjandra 2008	Control group	Mean±SD	60	88.5±42.6				Only performed at baseline.
Tjandra 2008	SNS group	Mean±SD	53	83.2±39.6			90.2±54.9	P > 0.05 at all time points compared with baseline. Follow‐up was at 12 months.
Vaizey 2000#		Mean (range)	2	100 (80 and 120)	65 (60 and 70)	95 (90 and 100)
Vaizey 2000#
Squeeze pressure duration (seconds)
Leroi 2005#	Group of 19 who chose 'on' following the crossover period	Median (range)	Baseline: 19 'Off' period: 13 'On' period: 17 Follow‐up: 19	15 (0 to 45)	21 (4 to 32)	18 (6 to 92)	22 (0 to 110)
Leroi 2005#	Group of 5 who chose 'off' following the crossover period	Median (range)	Baseline: 5 'Off' period: 5 'On' period: 5 Follow‐up: 5	20 (5 to 28)	40 (5 to 40)	32 (23 to 38)	25 (4 to 40)
Rectal volume sensation ‐ threshold (ml)
Leroi 2005#	Group of 19 who chose 'on' following the crossover period	Median (range)	Baseline: 17 Follow‐up: 18	25 (10 to 120)	Not reported	Not reported	30 (10 to 120)
Leroi 2005#	Group of 5 who chose 'off' following the crossover period	Median (range)	Baseline: 5 Follow‐up: 5	10 (10 to 40)	Not reported	Not reported	10 (10 to 50)
Sørensen 2010#		Mean (95% CI for mean)	7		50.0 (34.6 to 65.4)	27.1 (17.8 to 36.4)
Sørensen 2010#
Vaizey 2000#		Mean (range)	2	45 (both 45)	38 (25 and 50)	68 (45 and 90)
Vaizey 2000#
Rectal volume sensation ‐ urge (ml)
Sørensen 2010#		Mean (95% CI for mean)	7		82.9 (64.8 to 101)	60 (48.7 to 71.3)
Sørensen 2010#
Vaizey 2000#		Mean (range)	2	68 (65 and 70)	85 (70 and 100)	103 (85 and 120)
Vaizey 2000#
Rectal volume sensation ‐ maximal tolerated (ml)
Leroi 2005#	Group of 19 who chose 'on' following the crossover period	Median (range)	Baseline: 17 Follow‐up: 17	185 (80 to 350)	Not reported	Not reported	170 (40 to 275)
Leroi 2005#	Group of 5 who chose 'off' following the crossover period	Median (range)	Baseline: 5 Follow‐up: 5	200 (80 to 300)	Not reported	Not reported	195 (100 to 300)
Sørensen 2010#		Mean (95% CI for mean)	7		124 (106 to 142)	124 (82.4 to 165.6)
Sørensen 2010#
Vaizey 2000#		Mean (range)	2	118 (95 and 140)	135 (120 and 150)	140 (130 and 150)
Vaizey 2000#
Rectal volume sensation ‐ constant sensation volume (ml)
Leroi 2005#	Group of 19 who chose 'on' following the crossover period	Median (range)	Baseline: 17 Follow‐up: 18	100 (40 to 230)	Not reported	Not reported	85 (30 to 300)
Leroi 2005#	Group of 5 who chose 'off' following the crossover period	Median (range)	Baseline: 5 Follow‐up: 5	50 (20 to 90)	Not reported	Not reported	50 (20 to 95)