Anorectal manometry
Study	Measure	Patients	Baseline	One year	'Off' period	'On' period	Notes
Maximal resting pressure (cm H₂0)
Kenefick 2002#	Mean (range)	2	75 (65 and 84)	85 (82 and 87)	51 (39 and 63)	76 (68 and 84)	Stationary pull‐through technique
Maximal squeeze pressure (cm H₂0)
Kenefick 2002#	Mean (range)	2	39 (32 and 46)	78 (52 and 104)	54 (51 and 57)	93 (41 and 145)
Rectal volume sensation ‐ threshold (ml air)
Kenefick 2002#	Mean (range)	2	46 (45 and 47)	40 (20 and 60)	35 (30 and 40)	18 (15 and 20)
Rectal volume sensation ‐ urge (ml air)
Kenefick 2002#	Mean (range)	2	130 (75 and 185)	55 (35 and 75)	70 (60 and 80)	34 (33 and 35)
Rectal volume sensation ‐ maximal tolerated (ml air)
Kenefick 2002#	Mean (range)	2	194 (143 and 245)	83 (65 and 100)	103 (85 and 120)	68 (65 and 70)