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. 2022 May 13;6(6):e722. doi: 10.1097/HS9.0000000000000722

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Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Circulating CXCR4^lowCD5^high CLL cells exhibit increased metabolic activity. Primary CLL cells were incubated with 2NBDG (A), MitoTracker Green (B), TMRM (C), and DCF (D), labeled with CXCR4 and CD5 antibodies and analyzed by flow cytometry. CXCR4^highCD5^low, intermediate and CXCR4^lowCD5^high fractions were gated as ~5% of the whole population. The MFI of the metabolic markers is shown relative to intermediate fraction which was set 1. Results in (A, B, D) represent data obtained from 6 different CLL samples in two independent experiments, (C) 8 different CLL samples in 2 independent experiments. Graphs represent mean with standard deviation. CLL = chronic lymphocytic leukemia; MFI = median fluorescent intensity; TMRM = tetramethylrhodamine, methyl ester; DCF = dichlorodihydrofluorescin.