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. 2022 Jun 21;39(6):467–475. doi: 10.1007/s40266-022-00948-9

Table 2.

Comparison of psychotropic drug prescriptions between GUs and PSUs prior to the coronavirus disease 2019 pandemic

GU, n = 511 PSU, n = 163 p value
Drugs, median (IQR) 7 (5) 7 (4) 0.580
Psychotropic drugs, median (IQR) 1 (1) 2 (1) < 0.001*
 No psychotropic drugs 114 (22.3) 9 (5.5)
 1 treatment group 165 (32.3) 30 (18.4)
 2 treatment groups 147 (28.8) 62 (38.0)
 ≥ 3 treatment groups 85 (16.6) 62 (38.0)
Antipsychotics 159 (31.1) 128 (78.5) < 0.001*
 Quetiapine 83 (52.2) 76 (59.4) 0.224
 Risperidone 39 (24.5) 37 (28.9) 0.403
 Olanzapine 11 (6.9) 16 (12.5) 0.107
 Clozapine 6 (3.8) 5 (3.9) 0.954
 Aripiprazole 9 (5.7) 1 (0.8) 0.047*
Equivalent risperidone, median (IQR) 1(2) 1.5 (3) 0.040
Equivalent risperidone >2 mg 48 (30.2) 51 (39.8) 0.100
Benzodiazepines 170 (33.3) 47 (28.8) 0.291
 Lorazepam 96 (56.5) 25 (53.2) 0.689
 Lormetazepam 38 (22.4) 11 (23.4) 0.879
 Diazepam 12 (7.1) 4 (8.5) 0.736
 Alprazolam 12 (7.1) 2 (4.3) 0.739
 Bromazepam 8 (4.7) 0 (0.0) 0.206
 Clorazepate 4 (2.4) 3 (6.4) 0.175
Equivalent lorazepam, median (IQR) 1 (1) 1 (1) 0.164
Antidepressants 281 (55.0) 114 (69.9) < 0.001*
 Trazodone 121 (43.1) 55 (48.2) 0.347
 SSRIs 113 (40.2) 46 (40.4) 0.980
 Mirtazapine 75 (26.7) 27 (23.7) 0.536
 SNRIs 51 (18.1) 12 (10.5) 0.061
 Vortioxetine 10 (3.6) 2 (1.8) 0.344
Antiepileptic drugs 110 (21.5) 60 (36.8) < 0.001*
 Pregabaline 47 (44.3) 31 (54.4) 0.252
 Levetiracetam 25 (23.6) 6 (10.5) 0.043*
 Valproic acid 11 (10.4) 8 (14.0) 0.488
 Gabapentine 2 (1.9) 7 (12.3) 0.009*
 Topiramate 4 (3.8) 4 (7.0) 0.452

Data are presented as n (%) unless otherwise stated

GU geriatric units, IQR interquartile range, PSU psychogeriatric units, SNRIs serotonin-norepinephrine reuptake inhibitor, SSRI selective serotonin reuptake inhibitors, *p < 0.05