2. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin increase grading.

Trial	ALT increased (grade 3 and above)	AST increased (grade 3 and above)	Blood bilirubin increased
Kayentao 2012	10 × ULN	10 × ULN	3 × ULN
Poravuth 2011 Rueangweerayut 2012 Sagara 2018 Tshefu 2010	5 × ULN	5 × ULN	2.5 × ULN
Roth 2018a Shin 2011	3 × ULN	3 × ULN	‐
Nelwan 2015	3 × ULN if associated with bilirubin > 2 × ULN	‐	‐

Abbreviations: ALT: alanine aminotransferase; AST: aspartate aminotransferase; ULN: upper limit of normal.