4. Pyronaridine‐artesunate (PY‐AS) versus artemether‐lumefantrine (AL): other reported outcomes.

Trial	Fever clearance time		Parasite clearance time
	PY‐AS	AL	PY‐AS	AL
Kayentao 2012	Median 8.1 h (95% CI 8.0 to 8.1)	Median 8.1 h (95% CI 8.0 to 15.8)	Median 24.1 h (95% CI 24.0 to 24.1)	Median 24.2 h (95% CI 24.1 to 32.0)
Roth 2018a	Median 1 day (1 to 1)	Median 1 day (1 to 1)	Median 1 day (1 to 2)	Median 2 days (1 to 2)
Tshefu 2010	Mean 13.6 h (SD 8.9)	Mean 14.8 h (SD 10.1)	Mean 23.3 h (SD 8.8)	Mean 26.5 h (SD 10.1)

Abbreviations: AL: artemether‐lumefantrine; CI: confidence interval; PY‐AS: pyronaridine‐artesunate; SD: standard deviation.