| Author (year) | Day | Elevation (x ULN) | Participants with raised liver enzymes % (n) | Liver injury severity | |||
| ALT | AST | Bilirubin |
Participants with > 1 raised liver enzyme (n) |
Severity index judgement | |||
| Bui 2020 | 0 | > 2.6 | 0 (0) | 0 (0) | 2.7 (4) | ‐ | ‐ |
| Bui 2020 | 7 | > 2.6 | 7.8 (12) | 4.8 (8) | 1.5 (2) | 0 | Mild |
| Bui 2020 | 28 | > 2.6 | 1.4 (2) | 4.8 (7) | 3.8 (5) | 1 | Mild1 |
| Leang 2016 | 0 to 7 | > 3 | ‐ | 4.9 (6) | ‐ | 0 | Mild |
| Leang 2016 | 7 | > 3 | 2.4 (3) | ‐ | ‐ | 0 | Mild |
| Leang 2016 | 3 | > 2 | ‐ | ‐ | 0.8 (1) | 0 | None2 |
| Abbreviations: ALT: alanine aminotransferase; AST: aspartate transaminase; ULN: upper limit of normal. | |||||||
| 1The 1 participant with > 1 raised liver enzyme result had ALT 5.1 x ULN and bilirubin 3.2 x ULN at day 28 (Bui 2020). The authors reported that this participant had falciparum malaria recrudescence at day 28, and that the increased liver enzymes were not thought to be treatment‐related. 2Elevated bilirubin alone does not indicate liver injury. | |||||||
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