Adverse event	Participants experiencing adverse event % (n)
	Baseline liver function results
	Normal	Abnormala	Unknown	All
Any adverse event	16.3 (167)	18.8 (3)	33.3 (4)	16.6 (174)
Drug‐related adverse effect	9.5 (663)	7.6 (12)	28.6 (10)	9.6 (685)
Adverse events leading to discontinuation of study drug	0.6 (42)	1.3 (2)	28.6 (10)	0.8 (54)
Severe adverse event	0.5 (35)	0 (0)	0 (0)	0.5 (35)
Life‐threatening adverse event	0.1 (7)	0.6 (1)	2.9 (1)	0.1 (9)
Blood and lymphatic system disorders	0.4 (31)	0.6 (1)	5.7 (2)	0.5 (34)
Cardiac disorders	0.1 (6)	0 (0)	0 (0)	0.1 (6)
Gastrointestinal disorders	7.1 (494)	7.0 (11)	28.6 (10)	7.2 (515)
Abbreviations: ALT: alanine aminotransferase; AST: aspartate aminotransferase; ULN: upper limit of normal.
aAbnormal baseline liver function test results defined as ALT/AST > 2 x ULN.