Date	Event	Description
8 January 2019	New citation required and conclusions have changed	We included four new studies: three published after the previous version of this review, Bukirwa 2014, and one that was not identified in the previous review. During re‐extraction of data from the previous studies we used a transparent, itemized, and replicable procedure that differed from that used in Bukirwa 2014. The inclusion of new studies has allowed a new comparison of pyronaridine‐artesunate and artesunate‐amodiaquine, and has led to changes in the certainty of the evidence in relation to the primary outcomes. This review update gives higher‐certainty evidence in relation to the effect of pyronaridine‐artesunate on raised alanine aminotransferase (ALT).
8 January 2019	New search has been performed	There is a new author team: Joseph Pryce, Paul Hine (new contact person). We use the term 'pyronaridine‐artesunate' in preference to 'artesunate‐pyronaridine' to reflect how most authors refer to the intervention. We have updated the Background to reflect changes in global epidemiology, current World Health Organization (WHO) guidelines, and other developments. We added the term 'pyramax' to the search strategy. We have replaced the quantitative analysis of secondary outcomes parasite clearance, fever clearance, and gametocyte carriage with a narrative synthesis, and comment on the reasons for doing so. We simplified the adverse events outcomes to reflect that elevated liver function tests are a primary area of interest. We itemized the procedure for data extraction to ensure that the process is transparent and replicable in future review updates. We have added further commentary regarding the data extraction process. We simplified the risk of bias assessment for adverse events. We abbreviated the content of tables to enable clear and succinct presentation. We incorporated risk of bias for adverse events assessments into the main risk of bias tables. We added an appendix to summarize our risk of bias assessment process.
11 November 2008	Amended	We converted to the new review format with minor editing.