Study	Reason for exclusion
Bui 2020	Not an RCT
Han 2020	Not an RCT
Huang 1988	Quasi‐RCT. Randomized according to order of admission
Huang 1989	Quasi‐RCT. Odd and even numbers used for allocation
Huang 1993	RCT: conducted in people with complicated falciparum malaria
Laman 2014	Trial registration (ACTRN12610000913077) planned to use pyronaridine‐artesunate, but not available due to concerns over hepatotoxicity at time of trial.
Leang 2016	Not an RCT: single‐arm observational study
Leang 2019a	Not an RCT
Leang 2019b	Not an RCT
Looareesuwan 1996	Not an RCT: clinical trial of 2 doses of pyronaridine monotherapy, with group given second dose recruited after results of first dose were analysed
Looareesuwan 2007	RCT: phase II dose‐ranging trial
Lutete 2021a	Not an RCT
Piola 2008	Not an RCT: phase II dose‐ranging study
Ramharter 2008	Not an RCT: open‐label dose‐escalation study
Roth 2018b	Did not report our outcomes of interest
Sagara 2014	Not an RCT: pooled analysis

Abbreviations: RCT: randomized controlled trial.