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. 2022 Jun 20;13:3518. doi: 10.1038/s41467-022-31268-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Illustration of in vivo stable-isotope tracing in Drosophila and the distribution of 390 labeled metabolites from 59 pathways in head tissues. b Hierarchical-clustering analysis of the labeled metabolites (n = 390). c Upper panels, labeling dynamics of metabolites in each cluster; black dots represent the median labeling extent (LE) values of metabolites in the cluster; black lines represent the fitted metabolic dynamics; error bands represent 95% confidence intervals. Bottom panels, enriched pathways in each cluster (p-values < 0.05; hypergeometric test). d The example of aspartate for the calculation of labeling rate k (n = 10 biological replicates in each time point); black dot represents median LE; whiskers represent ±s.d. e k-value distributions for metabolites in three clusters (n = 182, 68, 42 fitted metabolites in clusters 1, 2, and 3, respectively). The centerlines of the boxplots indicate the median values, the lower and upper lines in boxplots correspond to 25th and 75th quartiles, and the whiskers indicate the largest and lowest points inside the range defined by 1st and 3rd quartile plus 1.5 times interquartile ranges (IQR). f Heat map showing the mean k-values of metabolties from 19 significantly labeled pathways. Pathway names are provided in Supplementary Table 5. Source data are provided as a Source Data file.